The efficacy of platelet-rich plasma PRP


Androgenetic Alopecia (AGA) The most common cause of hair loss in men is with limited treatment options. Platema-filled therapy (PRP) is one of the newer treatment options in the management of AGA, which has shown positive results.

Aims and Objectives:
This study was aimed at comparing the clinical effectiveness of PRP therapy with minoxidil therapy.

Content and methods:
In the study, two groups were randomized in patients - Group A (given PRP therapy) and Group B (minoxin therapy given). Both groups continued over a period of 6 months, with the final analysis carried out with the help of global photography, hair pull testing, a standard hair growth questionnaire, patient satisfaction score; In addition, platelet counts in PRP were compared to determine if there is a clinical correlation between platelet concentration and clinical improvement. 

A total of 40 patients clinically diagnosed with AGA were registered in the study with 20 patients in each group. Four patients from Group A (PRP) and six Group B patients (minoxidil) were unable to complete the treatment for 6 months and were not eventually included.

Results:
At the end of 6 months, 30 patients were evaluated to compare the effectiveness of the intradermal PRP and topical minoxidil therapy. In the case of global photography, Group A (PRP) found a better result than Group B (minor titles). In a hair traction test, a hair growth questionnaire, and a patient satisfaction score, Group A was found to be better than Group B. The platelet count at the baseline was 3.07 ± 0.5 lac / mm and the number of platelets was 12.4 ± 1.7. prepared in the final PRP. Lc / mm improved significantly, and patients with higher platelets in PRP compared to patients with low platelets in PRP. There were side effects with minimal PRP therapy with better results that could improve patient compliance.


Introduction
Androgenetic alopecia (AGA) is a hereditary and andogenic dermatological disorder, characterized by lowering skin hair in a defined pattern. There is a change in the dynamics of hair leading to vellus transformation of terminal hair follicles. Due to the limited treatment options, it is of concern to dermatologists worldwide.

The medical treatment options approved in the US for US Food and Drug Administration (FDA) are a detailed minoxidil and oral finasteride. Various other treatments were tried near FDA-approved options.
Most of the current treatment options are slow to act as newer treatment methods with plasma therapy (PRP) rich in platelets have been continuously investigated. PRP is automatic platelet preparations in concentrated plasma. There are more than 20 growth factors (GF), including platelet derived GFs as part of the most important GFs, changing GF-ß, vascular endothelial GF, and GF-1 such as insulin together with their isforms. . In AGA, PRP stimulates stem cell differentiation, it increases the durability of dermal papilla cells, it increases anagen stage of the hair cycle, and increases perifollicular vascular flexibility through different mechanisms.

This study was aimed at comparing the clinical effectiveness of PRP therapy with minoxidil therapy which could help us to know the nature of a more effective, acceptable and safe therapy in AGA management.

Content and methods
The study was carried out over 1 year with effect from 1 July, 2016 to 30 June, 2017. This prospective study was aimed at comparing the clinical efficacy of intradermal PRP with minor minoroxin therapy to treat AGA patients.
Adopt a detailed history to discourage other causes of hair loss such as telogen effluvium, history of any drug, or history of any systemic diseases. Patients were asked about lifestyle-related factors such as smoking and ultraviolet exposure that can contribute to an AGA. Patients were asked about the family history of the AGA. A thorough clinical examination of eligible patients was carried out to eliminate any local dermatological disorder of the scalp, and a diagnosis of AGA was made; the AGA grade was assigned according to the criteria.
Conclusion:
PRP therapy can be a valuable alternative to current minoxidil therapy in the treatment of AGA.

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